Clinically relevant doses of methylphenidate elicit behavioral sensitization and impair cognition on drug withdrawal in normal adult rats

Methylphenidate (MPD), a psychostimulant, is the first line drug for improving cognitive performance in attention deficit hyperactivity disorder (ADHD). A non-prescription use of this also becoming increasingly known. growing rise its medical and nonmedical suggests that addictive.The present study was designed to ascertain reinforcing withdrawal effects clinically relevant doses methylphenidate on behavior normal adult rats. Potential addictive cognition were determined.Effects MPD monitored after administration as well using Morris Water Maze test. Taking behavioral sensitization an important contributing factor addiction; determined. Data analysis done SPSS version 13 by one-way two-way ANOVA (repeated measure design) where applicable; post hoc comparisons Tukey’s Repeated oral (0.5 1mg/kg) six days produced reduced daily food intake. After treatment rats repeatedly administered/withdrawal from repeated investigate behaviors. Results showed improvement administered with 1 mg/kg). Whereas, impaired short term memory, long memory retention. Doses which improve learning are potentially elicit sensitization. Use healthy subjects can impair below basal levels particularly conditions.